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1.
《Journal of dairy science》2022,105(5):4314-4323
We tested the hypothesis that the size of a beef cattle population destined for use on dairy females is smaller under optimum-contribution selection (OCS) than under truncation selection (TRS) at the same genetic gain (ΔG) and the same rate of inbreeding (ΔF). We used stochastic simulation to estimate true ΔG realized at a 0.005 ΔF in breeding schemes with OCS or TRS. The schemes for the beef cattle population also differed in the number of purebred offspring per dam and the total number of purebred offspring per generation. Dams of the next generation were exclusively selected among the one-year-old heifers. All dams were donors for embryo transfer and produced a maximum of 5 or 10 offspring. The total number of purebred offspring per generation was: 400, 800, 1,600 or 4,000 calves, and it was used as a measure of population size. Rate of inbreeding was predicted and controlled using pedigree relationships. Each OCS (TRS) scheme was simulated for 10 discrete generations and replicated 100 (200) times. The OCS scheme and the TRS scheme with a maximum of 10 offspring per dam required approximately 783 and 1,257 purebred offspring per generation to realize a true ΔG of €14 and a ΔF of 0.005 per generation. Schemes with a maximum of 5 offspring per dam required more purebred offspring per generation to realize a similar true ΔG and a similar ΔF. Our results show that OCS and multiple ovulation and embryo transfer act on selection intensity through different mechanisms to achieve fewer selection candidates and fewer selected sires and dams than under TRS at the same ΔG and a fixed ΔF. Therefore, we advocate the use of a breeding scheme with OCS and multiple ovulation and embryo transfer for beef cattle destined for use on dairy females because it is favorable both from an economic perspective and a carbon footprint perspective. 相似文献
2.
为推进病历数字化发展,并确保其信息的安全性,将以HIS电子病历系统为基础,采用安信数字签名技术和PKI或PMI系统搭建相信并加以任用的授权服务,经过针对实际的PKC和CA的确认、委托与管控构建整体的数字签名平台,完成电子病历数字签名功能设计,以加强电子文件的完整性、真实性和不可抵赖性。最后以某医院的XML结构化的电子病历系统为基础进行项目实施,完成了医护人员通过HIS的快速身份认证,和准确地数字签名。 相似文献
3.
文章结合北京新机场高速公路照明工程实例,阐述了常规照明控制系统的现状,分析了基于新兴的LoRa物联网技术智能照明控制方案的系统原理和系统构成、系统在高速公路智能照明控制领域的应用以及系统应用能达到的节能和管理效益的提升效果,并对系统的扩展应用前景做了研究分析。 相似文献
4.
无证书签名具有基于身份密码体制和传统公钥密码体制的优点,可解决复杂的公钥证书管理和密钥托管问题.Wu和Jing提出了一种强不可伪造的无证书签名方案,其安全性不依赖于理想的随机预言机.针对该方案的安全性,提出了两类伪造攻击.分析结果表明,该方案无法实现强不可伪造性,并在"malicious-but-passive"的密钥生成中心攻击下也是不安全的.为了提升该方案的安全性,设计了一个改进的无证书签名方案.在标准模型中证明了改进的方案对于适应性选择消息攻击是强不可伪造的,还能抵抗恶意的密钥生成中心攻击.此外,改进的方案具有较低的计算开销和较短的私钥长度,可应用于区块链、车联网、无线体域网等领域. 相似文献
5.
For nonlinear continuous–discrete systems, this paper elaborates a new accurate implementation of continuous–discrete cubature Kalman filter (CD-CKF). As the main contribution of this work, the new Kalman prediction stage begins by integrating the nonlinear continuous model for all the cubature sample vectors; the prior estimate state and covariance prediction are based on the weighted statistics of these integrated cubature sample vectors and the Gauss–Legendre approximation scheme. The new square root form CD-CKF is also derived and accurately implemented by combining with the modified variable stepsize NIRK. As the advantages of proposed approach, the complicated and error-prone processes of solving covariance differential equation or calculating derivatives are avoided, while the positive semi-definiteness of prior error covariance are numerically guaranteed. Simulations of traffic control scenarios further confirm the new approach’s superior filtering performance in both reliability and accuracy. 相似文献
6.
Kutele Mabude Jean-Claude Malela-Majika Muhammad Aslam Zhi Lin Chong Sandile C. Shongwe 《Quality and Reliability Engineering International》2021,37(4):1409-1435
The Mann-Whitney (MW) statistic is one of the most recommended two-sample statistical tests when the assumption of normality fails to hold due to its robustness and fascinating properties especially when small sample sizes are involved. In order to improve the sensitivity of the generally weighted moving average (GWMA) monitoring scheme toward the detection of large shifts, in this paper, a new distribution-free phase II composite Shewhart-GWMA (CSG) scheme is proposed using the MW U statistic. The performance of the proposed scheme is investigated using the average run-length (ARL) and average extra quadratic loss (AEQL) values through extensive simulations. The performance of this newly proposed monitoring scheme is found to be superior when compared to numerous memory-type MW schemes (some existing and others introduced in this paper) in many situations. An illustrative example is given to demonstrate the implementation of the CSG MW U scheme using real-life data. 相似文献
7.
Paola Songia Mattia Chiesa Valentina Alfieri Ilaria Massaiu Donato Moschetta Veronika Myasoedova Vincenza Valerio Laura Fusini Paola Gripari Marco Zanobini Paolo Poggio 《International journal of molecular sciences》2021,22(4)
Mitral valve prolapse (MVP) associated with severe mitral regurgitation is a debilitating disease with no pharmacological therapies available. MicroRNAs (miRNA) represent an emerging class of circulating biomarkers that have never been evaluated in MVP human plasma. Our aim was to identify a possible miRNA signature that is able to discriminate MVP patients from healthy subjects (CTRL) and to shed light on the putative altered molecular pathways in MVP. We evaluated a plasma miRNA profile using Human MicroRNA Card A followed by real-time PCR validations. In addition, to assess the discriminative power of selected miRNAs, we implemented a machine learning analysis. MiRNA profiling and validations revealed that miR-140-3p, 150-5p, 210-3p, 451a, and 487a-3p were significantly upregulated in MVP, while miR-223-3p, 323a-3p, 340-5p, and 361-5p were significantly downregulated in MVP compared to CTRL (p ≤ 0.01). Functional analysis identified several biological processes possible linked to MVP. In addition, machine learning analysis correctly classified MVP patients from CTRL with high accuracy (0.93) and an area under the receiving operator characteristic curve (AUC) of 0.97. To the best of our knowledge, this is the first study performed on human plasma, showing a strong association between miRNAs and MVP. Thus, a circulating molecular signature could be used as a first-line, fast, and cheap screening tool for MVP identification. 相似文献
8.
ABSTRACTWe present a finite difference method to solve a system of two Partial-Integro Differential Equations which arise from pricing an option under a Jump-Telegraph Diffusion Model for the underlying asset, considering the risk-neutral valuation formula under an equivalent martingale measure. This system is fully discretized using an Implicit–Explicit two-time level scheme and quadrature formulas. The resulting two tridiagonal algebraic linear systems are solved recursively using the Thomas Algorithm. Some numerical results are presented and the numerical order of convergence for the method is estimated. Finally, the robustness of the method is validated against an exact solution obtained for a perturbed problem. 相似文献
9.
In this paper, a combined compact finite difference method (CCD) together with alternating direction implicit (ADI) scheme is developed for two-dimensional linear and nonlinear hyperbolic telegraph equations with variable coefficients. The proposed CCD-ADI method is second-order accurate in time variable and sixth-order accurate in space variable. For the linear hyperbolic equation, the CCD-ADI method is shown to be unconditionally stable by using the Von Neumann stability analysis. Numerical results for both linear and nonlinear hyperbolic equations are presented to illustrate the high accuracy of the proposed method. 相似文献
10.
The minimum cost flow problem (MCFP) is the most generic variation of the network flow problem which aims to transfer a commodity throughout the network to satisfy demands. The problem size (in terms of the number of nodes and arcs) and the shape of the cost function are the most critical factors when considering MCFPs. Existing mathematical programming techniques often assume the cost functions to be linear or convex. Unfortunately, the linearity and convexity assumptions are too restrictive for modelling many real-world scenarios. In addition, many real-world MCFPs are large-scale, with networks having a large number of nodes and arcs. In this paper, we propose a probabilistic tree-based genetic algorithm (PTbGA) for solving large-scale minimum cost integer flow problems with nonlinear non-convex cost functions. We first compare this probabilistic tree-based representation scheme with the priority-based representation scheme, which is the most commonly-used representation for solving MCFPs. We then compare the performance of PTbGA with that of the priority-based genetic algorithm (PrGA), and two state-of-the-art mathematical solvers on a set of MCFP instances. Our experimental results demonstrate the superiority and efficiency of PTbGA in dealing with large-sized MCFPs, as compared to the PrGA method and the mathematical solvers. 相似文献